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KMID : 0870419980020010095
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Korean Journal of Hepato-Biliary-Pancreatic Surgery
1998 Volume.2 No. 1 p.95 ~ p.102
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Significance of EGFR and c-erbB-2 Expression in Extrahepatic Bile Duct Cancer
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Son Gil-Soo
Choi Sang-Yong
Seo Seong-Ok
Kim Young-Chul
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Abstract
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Until now, surgical treatment of bile duct carcinoma has been unsatisfactory. There have been few reports dealing with the clinical significance of epidermal growth factor receptor(EGFR) and c-erbB-2 in bile duct cancer. To evaluate epidermal growth factor receptor(EGFR) and c-erbB-2 protein as a marker for prognosis, we analyzed the data and outcome of 32 cases of extrahepatic bile duct carcinoma immunohistologically, as well as clinicopathologically. The expressions of EGFR and c-erbB-2 showed in 71.9%(23/32) and 34.4%(11/32), respectively. The expression of EGFR was closely associated with the expression of c-erbB-2 (p<0.05). The expression rate of EGFR was significantly higher in well-differentiated cancer than in poorly-differentiated cancer (p<0.05), but was not related to stage, or lymph node metastasis. The expression of c-erbB-2 was not related to stage, lymph node metastasis, and differentiation. The expressions of EGFR and c-erbB-2 did not correlate with survival. In conclusion, the expression of EGFR or c-erbB-2 may be used as a tumor marker, but not as a prognostic factor in extrahepatic bile duct cancer.
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KEYWORD
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Extrahepatic bile duct cancer, EGFR, c-erbB-2
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